Which oncoprotein of high-risk human papillomavirus (HPV) binds the tumour suppressor p53 and promotes its degradation?

E6 of high-risk HPV forms a complex with the cellular ubiquitin ligase E6AP, which tags p53 for destruction in the proteasome, so the infected cell loses this check on its growth. E7 acts on a different tumour suppressor, the retinoblastoma protein (pRb), releasing E2F to drive the cell cycle. E2 is a viral regulator of transcription, and E5 is a small membrane protein; neither is the protein that degrades p53.