Sickle Cell Anaemia is caused due to
Question and options
Sickle Cell Anaemia is caused due to
- Single point mutation
- Inversion
- Deletion
- Frame shift mutation
Answer and explanation
Correct answer: A - Single point mutation
Sickle-cell anaemia is caused by a single point (missense) mutation in the beta-globin gene: GAG becomes GTG, so glutamic acid at position 6 is replaced by valine. The reading frame is not shifted and no segment is deleted or inverted, so frame-shift, deletion and inversion are wrong.
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