In which of the following syndrome there is presence of predominant conjugated hyperbilirubinaemia?
Dubin Johnson syndrome causes predominantly conjugated hyperbilirubinaemia due to an inherited defect in canalicular excretion of conjugated bilirubin into bile. Gilbert's…
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In which of the following syndrome there is presence of predominant conjugated hyperbilirubinaemia?
Answer and explanation
Correct answer D
Dubin Johnson syndrome causes predominantly conjugated hyperbilirubinaemia due to an inherited defect in canalicular excretion of conjugated bilirubin into bile. Gilbert's syndrome and Crigler-Najjar syndromes (Types 1 and 2) result from reduced hepatic UDP-glucuronosyltransferase activity and therefore cause unconjugated hyperbilirubinaemia.
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