I-cell disease is caused by
Question and options
I-cell disease is caused by
- Lack of lysosomal enzymes
- Imbalance in chloride and sodium
- Mutation in LDL receptor
- Uncontrolled autophagy
Answer and explanation
Correct answer: A - Lack of lysosomal enzymes
I-cell disease: a defective phosphotransferase prevents mannose-6-phosphate tagging, so lysosomal enzymes are secreted instead of reaching lysosomes; lysosomes lack their enzymes. An imbalance of chloride and sodium transport is the defect in cystic fibrosis, and a mutated LDL receptor causes familial hypercholesterolaemia.
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