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Which of the following is a metabolite of heroin?

Question and options

Which of the following is a metabolite of heroin?
  1. 6-Monoacetylmorphine
  2. N-acetyl-p-benzoquinone imine
  3. Triacetylmorphine
  4. Vanillylmandelic acid

Answer and explanation

Correct answer: A - 6-Monoacetylmorphine
Heroin (diacetylmorphine) is rapidly deacetylated to 6-monoacetylmorphine, a specific marker of heroin use, and then to morphine. NAPQI is from paracetamol and VMA from catecholamines.

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